Huntington’s disease is a rare disorder that affects the brain cells, leading to several physical, cognitive, and emotional symptoms. It is a hereditary neurodegenerative disease that attacks the central nervous system. It’s important to note that there is currently no cure for it. However, understanding the early causes of the disease, assessing risks, and identifying signs and symptoms of Huntington’s disease in detail will provide a comprehensive understanding of this condition. Causes The following are the genetic causes linked to the development and progression of Huntington’s disease (HD). Genetic mutation HD is caused by a mutation in the HTT gene, which is on chromosome 4 in the DNA segment. This mutation causes the production of mutant huntingtin (mHTT), which is an abnormal protein. Excess protein accumulation The mutant huntingtin protein has a tendency to aggregate and form clusters within neurons, interfering with their function and causing damage to brain function. This mutant protein is toxic to nerve cells, particularly in certain regions of the brain, leading to their dysfunction and eventual death. Impaired cellular transport Nerve and cell damage disrupts the transport of vital molecules within neurons. This affects one’s ability to communicate and function properly to facilitate tasks and familiar actions.